CHROMOSOME ABERRATIONS INDUCED BY CLINICAL MEDICINES
نویسندگان
چکیده
منابع مشابه
Quantitative analysis of radiation-induced chromosome aberrations.
We review chromosome aberration modeling and its applications, especially to biodosimetry and to characterizing chromosome geometry. Standard results on aberration formation pathways, randomness, dose-response, proximity effects, transmissibility, kinetics, and relations to other radiobiological endpoints are summarized. We also outline recent work on graph-theoretical descriptions of aberratio...
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The classical cytogenetic assay relies on the scoring of chromosomal damage in cells at metaphase. According to the standard protocol the analysis is confined to cells at the 1st post-irradiation mitosis collected at one, early sampling time. For sparsely ionizing radiation this protocol allows a reasonable estimate of chromosomal damage, because in all commonly used cell system no or only a sl...
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The discovery of Lilly and Thoday, that the presence of potassium cyanide (KCN) increases the production of chromosome aberrations by x-rays in anoxia, but has no effect on the production of chromosome aberrations by x-rays in air, was confirmed. In the presence of cyanide, the effect of a given dose of x-rays in nitrogen was found to be even greater than the effect of the same dose of x-rays i...
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The interest in the genetic and cytological effects of cyanide was greatly stimulated by the accumulation of data which indicated that hydrogen peroxide was involved in the production of mutations and chromosome aberrations by radiations (46, 43). If hydrogen peroxide is an important cause of mutation and chromosome breakage it would be expected that by inhibiting catalase and peroxidase (the e...
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Structural chromosome aberrations or chromosome mutations represent apart from aneuploidies the most frequent pathologic findings in applied chromosome diagnostics. But they also occur as combinations of both types as in unstable rearrangements or in chaotic karyotypes of early stages of embryonic development. Depending on the indication for chromosome analysis—child with developmental retardat...
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ژورنال
عنوان ژورنال: The Journal of Toxicological Sciences
سال: 1980
ISSN: 0388-1350,1880-3989
DOI: 10.2131/jts.5.141